TargetNEDD8-activating enzyme E1 regulatory subunit(Homo sapiens (Human))
Southwest Jiaotong University
Curated by ChEMBL
Southwest Jiaotong University
Curated by ChEMBL
Affinity DataIC50: 0.5nMAssay Description:Inhibition of NAE (unknown origin)More data for this Ligand-Target Pair
TargetNEDD8-activating enzyme E1 regulatory subunit(Homo sapiens (Human))
Southwest Jiaotong University
Curated by ChEMBL
Southwest Jiaotong University
Curated by ChEMBL
Affinity DataIC50: 4.70nMAssay Description:Inhibition of NAE (unknown origin)More data for this Ligand-Target Pair
TargetNEDD8-activating enzyme E1 regulatory subunit(Homo sapiens (Human))
Southwest Jiaotong University
Curated by ChEMBL
Southwest Jiaotong University
Curated by ChEMBL
Affinity DataIC50: 10nMAssay Description:Inhibition of NAE (unknown origin) in presence of ATPMore data for this Ligand-Target Pair
TargetNEDD8-activating enzyme E1 regulatory subunit(Homo sapiens (Human))
Southwest Jiaotong University
Curated by ChEMBL
Southwest Jiaotong University
Curated by ChEMBL
Affinity DataIC50: 180nMAssay Description:Inhibition of NAE (unknown origin)-mediated neddylation assessed as suppression of cullin1-Nedd8 adduct formation preincubated for 10 mins followed b...More data for this Ligand-Target Pair
TargetNEDD8-activating enzyme E1 regulatory subunit(Homo sapiens (Human))
Southwest Jiaotong University
Curated by ChEMBL
Southwest Jiaotong University
Curated by ChEMBL
Affinity DataIC50: 260nMAssay Description:Inhibition of NAE1 (unknown origin)More data for this Ligand-Target Pair
TargetNEDD8-activating enzyme E1 regulatory subunit(Homo sapiens (Human))
Southwest Jiaotong University
Curated by ChEMBL
Southwest Jiaotong University
Curated by ChEMBL
Affinity DataIC50: 800nMAssay Description:Inhibition of NAE (unknown origin)-catalyzed NEDD8-Ubcl2 intermediate formation by densitometric analysisMore data for this Ligand-Target Pair
TargetNEDD8-activating enzyme E1 regulatory subunit(Homo sapiens (Human))
Southwest Jiaotong University
Curated by ChEMBL
Southwest Jiaotong University
Curated by ChEMBL
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of NAE (unknown origin) assessed as decrease in NEDD8-Ubcl2 formationMore data for this Ligand-Target Pair
TargetNEDD8-activating enzyme E1 regulatory subunit(Homo sapiens (Human))
Southwest Jiaotong University
Curated by ChEMBL
Southwest Jiaotong University
Curated by ChEMBL
Affinity DataIC50: 5.51E+3nMAssay Description:Inhibition of NAE (unknown origin)-mediated neddylation assessed as suppression of cullin1-Nedd8 adduct formation preincubated for 10 mins followed b...More data for this Ligand-Target Pair
TargetNEDD8-activating enzyme E1 regulatory subunit(Homo sapiens (Human))
Southwest Jiaotong University
Curated by ChEMBL
Southwest Jiaotong University
Curated by ChEMBL
Affinity DataIC50: 6.67E+3nMAssay Description:Inhibition of NAE (unknown origin)-mediated neddylation assessed as suppression of cullin1-Nedd8 adduct formation preincubated for 10 mins followed b...More data for this Ligand-Target Pair
TargetNEDD8-activating enzyme E1 regulatory subunit(Homo sapiens (Human))
Southwest Jiaotong University
Curated by ChEMBL
Southwest Jiaotong University
Curated by ChEMBL
Affinity DataIC50: 9.94E+3nMAssay Description:Inhibition of NAE (unknown origin)-mediated neddylation assessed as suppression of cullin1-Nedd8 adduct formation preincubated for 10 mins followed b...More data for this Ligand-Target Pair
TargetNEDD8-activating enzyme E1 regulatory subunit(Homo sapiens (Human))
Southwest Jiaotong University
Curated by ChEMBL
Southwest Jiaotong University
Curated by ChEMBL
Affinity DataIC50: 1.64E+4nMAssay Description:Inhibition of NAE (unknown origin)-mediated neddylation assessed as suppression of cullin1-Nedd8 adduct formation preincubated for 10 mins followed b...More data for this Ligand-Target Pair
TargetNEDD8-activating enzyme E1 regulatory subunit(Homo sapiens (Human))
Southwest Jiaotong University
Curated by ChEMBL
Southwest Jiaotong University
Curated by ChEMBL
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of NAE (unknown origin)-catalyzed transthiolation of NEDD8 from NAE to Ubc12More data for this Ligand-Target Pair
TargetNEDD8-activating enzyme E1 regulatory subunit(Homo sapiens (Human))
Southwest Jiaotong University
Curated by ChEMBL
Southwest Jiaotong University
Curated by ChEMBL
Affinity DataEC50: 3.56E+3nMAssay Description:Inhibition of Protein kinase C delta expressed in Sf-9 cellsMore data for this Ligand-Target Pair
TargetNEDD8-activating enzyme E1 regulatory subunit(Homo sapiens (Human))
Southwest Jiaotong University
Curated by ChEMBL
Southwest Jiaotong University
Curated by ChEMBL
Affinity DataEC50: 3.56E+3nMAssay Description:Inhibition of NAE-mediated neddylation in human MGC-803 cells assessed as effect on NEDD8-UBC12 coupling product formationMore data for this Ligand-Target Pair